منابع مشابه
Prediction of Type 1 Diabetes
Type 1 diabetes (T1D) is a chronic autoimmune disorder in which the destruction of the insulinproducing cells and resulting clinical symptoms are preceded by the appearance of a number of islet-cell specific autoantibodies. Linkage (1) and association analyses have demonstrated that type 1 diabetes has a very strong genetic component, with specific alleles and haplotypes at the HLA class II gen...
متن کاملprevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study
چکیده ندارد.
15 صفحه اولAntigen-based prediction and prevention of type 1 diabetes.
2. INTRODUCTION Type 1 (insulin dependent) diabetes develops as the result of a cumulative autoimmune-mediated destruction of the pancreatic beta cells mainly in genetically predisposed individuals. The disease becomes clinically manifest when 50-90% of the beta cells are destroyed (1) following a long prodromal period (months to years) during which autoimmune phenomena are often present, inclu...
متن کاملDeficiencies of cardiovascular risk prediction models for type 1 diabetes.
OBJECTIVE Cardiovascular risk prediction models are available for the general population (Framingham) and for type 2 diabetes (U.K. Prospective Diabetes Study [UKPDS] Risk Engine) but may not be appropriate in type 1 diabetes, as risk factors including younger age at diabetes onset and presence of diabetes complications are not considered. Therefore, our objective was to examine the accuracy of...
متن کاملPrediction of Type 1 Diabetes in the General Population
OBJECTIVE To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS A total of 3,475 nondiabetic subjects aged 3-18 years were sampled in 1980, and 2,375 subjects (68.3%) were resampled in 1986. All subjects were...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2013
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-1593